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CSF3R S783fs/BaF3

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產(chǎn)品型號(hào)CBP73255

品牌cobioer/科佰生物

廠商性質(zhì)代理商

所在地南京市

更新時(shí)間:2022-05-06 09:25:33瀏覽次數(shù):644次

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供貨周期 現(xiàn)貨 規(guī)格 T-25 Flask
貨號(hào) CBP73255 應(yīng)用領(lǐng)域 生物產(chǎn)業(yè)
主要用途 僅限科研使用
CSF3R S783fs/BaF3,母細(xì)胞:BaF3,CSF3R,集落刺激因子 3 受體,編碼調(diào)節(jié)骨髓祖細(xì)胞增殖和分化的細(xì)胞因子受體(PMID:27789332)。 CSF3R 突變常見于慢性中性粒細(xì)胞白血病和急性髓系白血病(PMID:23896413,PMID:30348809)。


CBP73255

I. Introduction

Cell Line Name:

CSF3R S783fs/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative

II.Background

CSF3R S783fs results in a change in the amino acid sequence of the Csf3r protein beginning at aa 783 of 836, likely resulting in premature truncation of the functional protein (UniProt.org). S783fs does not result in increased Stat3 activation (PMID: 23656643, PMID: 24403076), however, results in increased Src activation and transformation in cell culture (PMID: 23656643), and therefore, is predicted to result in a gain of Csf3r protein function.

III. Representative Data

1.WB of  CSF3R S783fs/BaF3

CBP73255 WB.png


2. Anti-proliferation assay

CBP73255-2.jpg

Figure 2. Anti-proliferation assay of three reference compounds on the CSF3R S783fs/BaF3.


CD74-ROS1 G2032R BaF3

CD74-ROS1 [G2032R] BaF3

CD74-ROS1 L2086F BaF3

CD74-ROS1 [L2086F] BaF3

KRAS G12D&Y96C BaF3

KRAS [G12D&Y96C] BaF3

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