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南京科佰生物科技有限公司

中級會員 | 第11年

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產(chǎn)品型號CBP73222

品牌cobioer/科佰生物

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藥靶細(xì)胞株: hIO-Mouse 核受體其他細(xì)胞示蹤細(xì)胞株耐藥株腫瘤免疫細(xì)胞株 kinase激酶細(xì)胞株 GPCR細(xì)胞株

產(chǎn)品簡介

EGFR V769_D770insGVV/BaF3,母細(xì)胞：BaF3，凍存條件：90% FBS+10% DMSO

CBP73222
I. Introduction
Cell Line Name：	EGFR V769_D770insGVV/BaF3
Host Cell:	Ba/F3
Stability:	16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Application:	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Freeze Medium:	90% FBS+10% DMSO
Complete Culture Medium:	RPMI-1640+10%FBS
Mycoplasma Status:	Negative

II.Background
EGFR V769_D770insGVV results in the insertion of three amino acids in the protein kinase domain of the Egfr protein between amino acids 769 and 770 (UniProt.org). V769_D770insGVV has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions (PMID: 24353160).

III. Representative Data
1. WB of EGFR V769_D770insGVV/BaF3
2. Anti-proliferation assay