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南京科佰生物科技有限公司

中級會員 | 第11年

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產(chǎn)品型號CBP73241

品牌cobioer/科佰生物

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所在地南京市

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藥靶細(xì)胞株: hIO-Mouse 核受體其他細(xì)胞示蹤細(xì)胞株耐藥株腫瘤免疫細(xì)胞株 kinase激酶細(xì)胞株 GPCR細(xì)胞株

產(chǎn)品簡介

FLT3-ITD [D835del]/BaF3,母細(xì)胞：BaF3，凍存條件：90% FBS+10% DMSO

CBP73241
I. Introduction
Cell Line Name：	FLT3-ITD [D835del]/BaF3
Host Cell:	Ba/F3
Stability:	16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:	90% FBS+10% DMSO
Complete Culture Medium:	RPMI-1640+10%FBS+2ug/ml puromycin
Mycoplasma Status:	Negative

II.Background
FLT3, receptor-type tyrosine-protein kinase FLT3, activates Akt, Ras, and Erk pathways to regulate differentiation, proliferation, and survival of hematopoietic progenitor cells (PMID: 29316714, PMID: 28538663). Activating mutations of FLT3 are common in hematologic tumors (PMID: 19467916) and the internal tandem duplication (ITD) mutation is commonly observed in acute myeloid leukemia (PMID: 30181385).

III. Representative Data
1.FLT3-ITD [D835del]/BaF3
2. Anti-proliferation assay
Figure . Anti-proliferation assay of three reference compounds on the FLT3-ITD [D835del]/BaF3 Stable Cell Line.