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【產品簡介】
【詳細說明】
GsAF-II
Blocker of Nav1.1 / 1.2 / 1.3 / 1.4 / 1.6 / 1.7
鈉離子通道Nav1.1 / 1.2 / 1.3 / 1.4 / 1.6 / 1.7阻斷劑
GsAF-II (also termed Kappa-theraphotoxin-Gr2c, GsAF-2) was originally isolated from the venom of Grammostola rosea spider. GsAF-II peptide toxin has antinociceptive and antiarrhythmic effects in mammals. The peptide is reported to block the following voltage-gated sodium channels: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with IC50 values of, respectively, 5.7, 12, 24, 4, 6.6 and 1.3 µM. This peptide also blocks hERG1 with an IC50 value of 4.7 µM.
GsAF-II 技術資料
氨基酸序列：
Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp-Glu-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Leu-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Lys-Lys-Ile-Glu-Trp-OH
二硫鍵：Cys2-Cys16, Cys9-Cys21, and Cys15-Cys25
長度 (aa)：31
分子式：C176H261N47O45S7
分子量： 3979.78 Da
外觀：White lyophilized solid
可溶性：aqueous buffer
CAS 號：not available
來源：Synthetic
純度：> 98%
產品信息
12GSF002-00100 | GsAF-II | 0.1mg |
12GSF002-00500 | GsAF-II | 0.5mg |
12GSF002-01000 | GsAF-II | 1mg |