欧美国产日韩在线免费观看-欧美日韩成人激情一区二区-欧美久久综合一区二区-亚洲av寂寞少妇久久

The CD123 protein, also known as the Interleukin-3 receptor subunit alpha （IL-3RA） or CD123, is a crucial component of the interleukin-3 （IL-3） receptor complex and belongs to the Type I cytokine receptor family, specifically the Class 5 subfamily. CD123 serves as the high-affinity receptor for IL-3, forming a heterodimeric receptor complex with the β chain （CSF2RB）. This protein mediates the stimulatory effects of IL-3 on the proliferation and differentiation of various hematopoietic cells, including pluripotent hematopoietic stem cells and lineage-committed cells. CD123 is expressed on normal plasmacytoid dendritic cells, basophils, monocytes, and eosinophils, and is overexpressed in various hematologic malignancies. In clinical research, the expression of CD123 is associated with chemotherapy resistance and high-risk genetic alterations in certain leukemias, such as acute myeloid leukemia （AML）.