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CD14, also known as the LPS receptor, is a surface antigen belonging to the family of cell surface glycoproteins. It exists in two forms: membrane-bound CD14 （mCD14）, which is anchored to the cell membrane via a glycosylphosphatidylinositol （GPI） tail, and soluble CD14 （sCD14）, found in the plasma. CD14 is primarily expressed on monocytes, macrophages, and dendritic cells, and plays a critical role in the immune system by recognizing and binding to lipopolysaccharide （LPS） from Gram-negative bacteria, leading to cellular activation and the initiation of inflammatory responses.