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CD196, also known as CCR6, is a seven-transmembrane, G-protein-coupled receptor that belongs to the beta chemokine receptor family. It is predominantly expressed on B lymphocytes, certain subsets of effector and memory T cells, and immature dendritic cells. CCR6 is a receptor for the CC chemokine CCL20 and also binds with lower affinity to beta-defensin 2. This receptor plays a crucial role in mediating the trafficking of immune cells to epithelial sites near the skin and mucosal surfaces during inflammatory and immunological responses.