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CD186, also known as CXCR6, is a 39 kD G-protein coupled chemokine receptor with seven transmembrane-spanning regions. It is expressed on various immune cells, including activated and memory T cells, NKT cells, and some plasma cells. Its ligand is CXCL16, which is expressed by macrophages, dendritic cells, and liver endothelial cells. CD186 plays a role in cell migration and recruitment to inflamed sites and is also a coreceptor for HIV and SIV.