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Neuron specific enolase （NSE） is a phosphopyruvate hydratase and is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. NSE as a serum biomarker has been widely used in diagnosis of various malignant tumors in clinical, and it has been found to be associated with melanoma, seminoma, renal cell carcinoma, Merkel cell tumor, carcinoid tumors, dysgerminomas, and immature teratomas, especially small cell lung cancer （SCLC）.