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Bcl-2 （B-cell lymphoma 2） is the founding member of the Bcl-2 family of regulator proteins that regulate cell death （apoptosis）, by either inhibiting （anti-apoptotic） or inducing （pro-apoptotic） apoptosis. It was the first apoptosis regulator identified in any organism. Bcl-2 is localized to the outer membrane of mitochondria, where it plays an important role in promoting cellular survival and inhibiting the actions of pro-apoptotic proteins. Damage to the Bcl-2 gene has been identified as a cause of a number of cancers, including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung cancer, and a possible cause of schizophrenia and autoimmunity. It is also a cause of resistance to cancer treatments.