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Chromogranin A （CgA） is a prohormone and granulogenic factor in endocrine and neuroendocrine tissues, as well as in neurons, and has a regulated secretory pathway [PMID: 28228748]. Chromogranin A is known as an important marker of neuroendocrine tumors [PMID: 24325234]. The intracellular functions of CgA include the initiation and regulation of dense-core granule biogenesis and sequestration of hormones in neuroendocrine cells. This protein is co-stored and co-released with secreted hormones. The extracellular functions of CgA include the generation of bioactive peptides, such as pancreastatin （PST）, vasostatin, WE14, catestatin （CST）, and serpinin [PMID: 28228748].