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This antibody recognizes the same epitope as clone 37.51.

This monoclonal antibody reacts with mouse CD28, a 45 kDa costimulatory receptor and a member of the lg superfamily, CD28 is expressed by thymocytes,?most peripheral T cells, and NK cells. CD28 is a receptor for CD80 （B7-1） and CD86 （B7-2）. Signaling through CD28 augments lL-2 and IL-2 receptor expression as?well as cytotoxicity of CD3-activated T cells. This antibody has been shown to stimulate the proliferation and cytokine production by activated T and NK cells?and provide a costimulatory signal for CTL induction.