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The regenerating gene （REG） family members, REG1～4, are small secreted lectin-like proteins involved in hepatic, pancreatic, gastric and intestinal cell proliferation and differentiation. It has been reported that aberrant expression of REG4 is associated with the growth, survival, adhesion and resistance to apoptosis of tumor cells. Furthermore, REG4 has been identified as one of the genes up-regulated in gastric cancer-initiating cells and is thus used as a novel marker for these cells.