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Myelin oligodendrocyte glycoprotein （MOG） is a member of the immunoglobulin superfamily and is expressed exclusively in the central nervous system. MOG （35-55） is able to induce autoantibody production and relapsing-remitting neurological disease causing extensive plaque-like demyelination. Autoantibody response to MOG （35-55） has been observed in multiple sclerosis （MS） patients and MOG （35-55）-induced experimental autoimmune encephalomyelitis （EAE） C57/BL6 mice and Lewis rats. Every lot of MOG （35-55） peptide is tested and proven to induce EAE.