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Thrombopoietin receptor （TPO-R）, also known as TPO-R, is predominantly expressed on the surface of megakaryocytes （MKs）, platelets, hemangioblasts, and hematopoietic stem cells （HSCs）. Binding of thrombopoietin （TPO） to the megakaryocyte TPO-R leads to several effects: prevention of megakaryocyte apoptosis, increased megakaryocyte number, size, and ploidy, accelerated maturation of megakaryocytes, and internalization of the TPO/TPO-R complex. Thrombopoietin R is involved in multiple signal transduction pathways, including JAK, STAT, and MAP kinase pathways.