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Matrix Metalloproteinase-2 （MMP-2） is an enzyme that degrades extracellular matrix components, playing a pivotal role in cell migration during physiological and pathological processes. Its expression is regulated by EMMPRIN, Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation requires MT1-MMP and TIMP-2. Low MMP-2 levels are associated with a favorable prognosis in hormone receptor-negative tumors, which are typically high-risk. As a zymogen requiring proteolytic activation, MMP-2 is broadly implicated in cancer invasion and metastasis, including human breast cancer. Blocking MMP-2 secretion and activation during breast carcinoma development may reduce metastasis. The detection of active MMP-2 or the ratio of pro-MMP-2 to active MMP-2 is a highly sensitive indicator of cancer metastasis. Modulating MMP-2 expression and activation via specific inhibitors or activators offers a promising therapeutic strategy for breast cancer treatment.