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作者： Seyda Bucak, Deverraux A. Jones, Paul E. Laibinis and T. Alan Hatton

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

 

摘要： Phospholipid-coated colloidal magnetic nanoparticles with mean magnetite core size of 8 nm are shown to be effective ion exchange media for the recovery and separation of proteins from protein mixtures. These particles have high adsorptive capacities (up to 1200 mg protein/mL adsorbent, an order of magnitude larger than the best commercially available adsorbents) and exhibit none of the diffusional resistances offered by conventional porous ion exchange media. Protein-laden particles are readily recovered from the feed solution using high-gradient magnetic filtration.