Programmed death-1 (PD-1)是在T細(xì)胞上表達(dá)的抑制性受體，它能促進(jìn)炎性T細(xì)胞的凋亡并抑制抗炎調(diào)節(jié)性T細(xì)胞的凋亡，從而提高自身耐受性并預(yù)防自身免疫性疾病。為了逃避免疫監(jiān)視，腫瘤細(xì)胞經(jīng)常通過(guò)過(guò)度表達(dá)PD-L1來(lái)利用這一系統(tǒng)，PD-L1是一種結(jié)合并激活PD-1的配體。抗PD-1單克隆抗體用于阻斷PD-L1與PD-1的結(jié)合，從而使免疫系統(tǒng)能夠發(fā)現(xiàn)并殺死腫瘤細(xì)胞。
BioXCell提供三種不同克隆號(hào)的anti mouse PD-1抗體，分別是: RMP1-14、29F.1A12和J43。
in vivo Antibodies
We have a growing library of 400+ antibodies specifically formulated for in vivo use-validated for purity and quality, readily-available in milligram to gram quantities, and quickly delivered.
Whether you need blocking antibodies against a specific target; functional antibodies or biosimilars to study biological effects; or quality anti-mouse antibodies to increase reproducibility, sensitivity, and specificity, you’ll find monoclonal antibodies (MAbs) for in vivo use that you can rely on.
InVivoPlus anti-mouse PD-1 (CD279)抗體
Catalog #BP0146 Clone:RMP1-14
| 同種型 | Rat IgG2a, κ |
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InVivoPlus anti-mouse PD-1 (CD279)抗體
Catalog #BP0146 Clone:RMP1-14
| 推薦的同型對(duì)照 | InVivoPlus rat IgG2a isotype control, anti-trinitrophenol |
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| Reported Applications | in vivo blocking of PD-1/PD-L signaling |
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