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The Thermo Scientific Pierce RED Device for Rapid Equilibrium Dialysis was developed in association with the pharmaceutical industry to provide the easiest, fastest and most reliable system for performing plasma protein-binding assays.

The Rapid Equilibrium Dialysis (RED) Device is an apparatus for performing equilibrium dialysis experiments in a high throughput, automation-compatible format. The RED device consists of disposable inserts and a base plate formatted to a standard microplate footprint. The RED Device has been extensively validated for plasma-binding assays and produces results consistent with those reported in the literature. The RED Device offers significant improvements in automation, time requirements, versatility and product reliability compared to other commercially available equilibrium dialysis systems.

Highlights:

• Easy and ready to use – disposable tubes require no presoaking, assembly or specialized equipment
• Designed for speed – the high surface-to-volume ratio of the insert design enables equilibrium to be reached in as few as 100 minutes with vigorous agitation or in three to four hours with 200rpm agitation
• Automation-compatible – designed on a standard 96-well plate template suitable for automated liquid handlers
• Flexible and scalable – perform any number of assays (1 to 48 assays per plate) without wasting the entire plate
• Robust – compartmentalized design eliminates potential for cross talk or leakage
• Reproducible and accurate – validated for plasma binding assays, producing results consistent with those reported in literature
• Quality-tested – each lot of inserts is functionally tested in a protein-binding assay for guaranteed performance