hCD19/A20
| I. Background | |
| CD19（Cluster of Differentiation 19）是一種跨膜糖蛋白，屬于免疫球蛋白超家族成員， 主要表達(dá)于 B 淋巴細(xì)胞譜系細(xì)胞表面，包括前 B 細(xì)胞、成熟 B 細(xì)胞及大多數(shù) B 細(xì)胞惡性腫 瘤細(xì)胞。其功能是作為 B 細(xì)胞受體（BCR）復(fù)合物的共受體，參與 B 細(xì)胞活化、增殖和分 化信號的傳導(dǎo)。CD19 作為 B 細(xì)胞惡性腫瘤的核心靶點(diǎn)，推動了 CAR-T 等精準(zhǔn)治療的 發(fā)展，顯著改善了患者預(yù)后。 | |
| II. Introduction | |
| Host Cell: | A20 |
| Expressed gene: | hCD19 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+10%FBS+0.05 mM 2-mercaptoethanol+1 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mus musculus, mouse |
| Tissue: | B lymphocyte |
| Morphology: | lymphoblast |
| Growth Properties: | suspension |
| IV. Representative Data | |
Figure 1. Recombinant hCD19/A20 stably expressing CD19. | |
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