OKT3單克隆抗體特異性地與CD3的ε鏈/T淋巴細胞抗原受體復合物發(fā)生反應。CD3的復合物包括 γ、 δ和ε鏈，它是TCR復合物的一部分，由成熟的T淋巴細胞和胸腺細胞譜系表達。CD3通過信號轉導增強抗原識別。而OKT3抗體是一種免疫抑制劑，在肝臟、心臟和腎臟同種異體移植排斥方面，這已被證明是一種有效的治療劑。

Description

The OKT3 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.

The OKT3 antibody is an immunosuppressive, which has proven to be an effective therapeutic agent in liver, heart, and renal allograft rejection.

質量控制

BioGems CD3單克隆抗體經過親和層析純化。

內毒素水平：蛋白質小于0.01 EU/µg，鱟試劑法檢測。

訂購信息

品牌	貨號	產品描述	包裝
BioGems	05121-25-500	Anti-Human CD3 SAFIRE Purified CD3單抗	500μg/支
BioGems	05121-25-100	Anti-Human CD3 SAFIRE Purified CD3單抗	100μg/支

**紅榮微再代理的BioGems CD3/CD28單抗正進行年末*活動：買二送一（四折之后），并贈送抗霾禮盒**

Biogems是Peprotech的抗體品牌。CD3/CD28單抗BioGems*現(xiàn)正進行4折*。

CD3 500ug 現(xiàn)價4130元 *(4折) 1652元

CD28 500ug 現(xiàn)價3640元 *(4折) 1456元

產品編號	產品名稱	克隆號
05121-25-500	Anti-Human CD3(SAFIRE)	OKT3
10311-25-500	Anti-Human CD28(SAFIRE)	CD28.2

BioGems的SAFIRE (Sodium Azide Free Immensely Reduced Endotoxins) 類產品是BioGems品牌下的功能性抗體產品，經特殊工藝生產、純化，具有諸多特點，可用于免疫細胞功能的激活、阻斷、中和研究，是腫瘤免疫研究的重要工具。

SAFIRE純化CD3單抗 (clone: OKT3)可以與TCR復合物結合，激活T細胞；SAFIRE純化CD28單抗 (clone: CD28.2)是 T細胞激活、增殖的輔助刺激分子。

紅榮微再*

CD3 CD28單抗買二送一！

在4折基礎上再加優(yōu)惠。

買二：CD3、CD28任選兩支。

送一：CD3、CD28任選一支。

贈送抗霾禮盒

抗霾禮盒

易可濾掛機空調伴侶防PM2.5空調過濾

易可濾防霧霾過濾PM2.5可更換式口罩

價值600多元

活動時間：2017年12月15日 - 2018年3月31日

歡迎您致電華雅再生醫(yī)學旗艦公司：紅榮微再（上海）生物工程技術有限公司：1500 1904 520。紅榮微再-客服: 經銷商專員

CD3單克隆抗體（OKT3）/抗人CD3抗體免疫細胞治療介紹：

CD3單克隆抗體（OKT3）/抗人CD3抗體是由肽鏈以非共價鍵組成的復合分子，在成熟T細胞表面表達，對阻斷急性同種異體排斥反應起主要作用。 CD3分子與TCR組成復合受體分子，激活酪氨酸激酶，促使CD3分子免疫受體酪氨酸活化基序中的酪氨酸（Y）磷酸化。磷酸化的酪氨酸（pY）進一步磷酸化下游含酪氨酸的蛋白，從而引起激酶活化的級聯(lián)反應，調控T細胞增殖和活化的靶基因，引起基因的表達和轉錄，T細胞由靜止狀態(tài)轉為增殖和活化狀態(tài)。

CD3分子具有穩(wěn)定TCR結構和傳遞活化信號的作用。針對CD3分子的單克隆抗體能夠激發(fā)或阻斷T細胞活化信號轉導，清除效應T細胞或誘導調節(jié)T細胞的產生。

說明書

Product Information

Clone: OKT3

Format/Conjugate: SAFIRE Purified

Concentration: 2 mg/mL

Reactivity: Human

Isotype: Mouse IgG2a, kappa

Formulation: Phosphate-buffered aqueous solution, ph7.2.

Applications: FC, FA, IHC

Research Interest: Adaptive Immunity

Cell Type: NK and NKT Cells, T Cells, Treg cells, Th17 cells

Preparation & Storage:The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Application Notes

The antibody has been analyzed for quality through the flow cytometric analysis of the relevant cell type. It is recommended that the reagent be titrated for optimal performance for each application.

For Research Use Only. Not for use in diagnostic procedures

Catalog Number : 05121-25

Description

The OKT3 antibody is an immunosuppressive, which has proven to be an effective therapeutic agent in liver, heart, and renal allograft rejection.

Additional Information

Clone OKT3

Format:SAFIRE Purified

Applications FC, FA, IHC

Reactivity Human

Isotype:Mouse IgG2a, kappa

Research Interest: Adaptive Immunity

Cell Type: NK and NKT Cells, T Cells, Treg cells, Th17 cells

Preperation:

The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Formulation:

Phosphate-buffered aqueous solution, ph7.2.

References:

Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York

Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.

Adair, J. R., Athwal, D. S., Bodmer, M. W., Bright, S. M., Collins, A. M., Pulito, V. L., ... & Jolliffe, L. K. (1994). Humanization of the murine anti-human CD3 monoclonal antibody OKT3. Human Antibodies, 5(1), 41-47.

歡迎您致電華雅再生醫(yī)學旗艦公司：紅榮微再（上海）生物工程技術有限公司：1500 1904 520。紅榮微再-客服: 經銷商專員