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Fibroblast growth factor 12 （FGF-12）, also known as fibroblast growth factor homologous factors （FHF）, is cytosolic proteins that is homologous to fibroblast growth factors but is not secreted. FGF12 modulates both cardiac Na+ and Ca+ channel by binding to the conserved proximal part of the C-terminal domain of voltage-gated sodium channels Nav1.5. However, a single missense mutation in FGF12-B （Q7R-FGF12） reduced binding to the NaV1.5 C-terminus, yielding a Brugada Syndrome phenotype.