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TNF-like cytokine 1A （TL1A） is a member of the TNF and TNF receptor superfamily. TL1A constitutes a cytokine system that actively interferes with the regulation of immune responses. TL-1A is predominantly expressed in endothelial cells and its expression is inducible by TNF-α and IL-1α. TL1A binds with high affinity to death receptor 3 （DR3）, known as TNFRSF25. Recombinant human TL1A is a 21 kDa polypeptide of 180 amino acid residues